|Description of Trichomes:
Glandular secreting trichomes (GST); non glandular simple trichomes (NGT).
Cistus creticus leaf trichomes consist of non glandular (stellate) and glandular, long, ball-headed, multi-cellular trichomes. Glandular trichomes are composed of a long multi-cellular stalk of over 200 micrometer toped by a small glandular head cell, In addition, two types of non-glandular trichome are present, multi-cellular stellate and simple unicellular spikes.
The resin excreted from these glands was known and used since ancient times for its officinal and aromatic properties. These traditional applications were corroborated by recent findings showing that the resin's labdane-type components such as ent-3'-acetoxy-13-epi-manoyl oxide, ent-13-epi-manoyl oxide, (13E)-labd-13-ene-8a,15-diol, (13E)-labd-7,13-diene-15-ol, (13E)-labd-7,13-diene-15-yl acetate, (13E)-labd-7,13-dienol, sclareol [(13R)-labd-14-ene-8,13-diol] or manoyl oxide derivatives, in free form or incorporated in liposomes, exhibited strong in vitro cytotoxic and cytostatic activity against human cancer lines.
1) Irene Paterakia and Angelos K. Kanellis (2008) Isolation and functional analysis of two Cistus creticus cDNAs encoding geranylgeranyl diphosphate synthase. doi:10.1016/ j.phytochem.2008.02.005
2) Gulz et al., 1996 P.G. Gulz, T. Herrmann and K. Hangst, Leaf trichomes in the genus Cistus, Flora 191 (1996), pp. 82-104.
3) Falara V, Fotopoulos V, Margaritis T, Anastasaki T, Pateraki I, Bosabalidis AM, Kafetzopoulos D, Demetzos C, Pichersky E, Kanellis AK. (2008) Transcriptome analysis approaches for the isolation of trichome-specific genes from the medicinal plant Cistus creticus subsp. creticus. Plant Mol Biol. 2008 Dec;68(6):633-51. Epub 2008 Sep 26.